A REVIEW ON PREPARATION OF METHODS OF CURCUMIN NANOPARTICLES

Preeti Singh Praveen Kumar Bhagyashree Goswami

Abstract


  • Curcumin is a profoundly intense, nontoxic, bioactive operator found in turmeric and has been referred to for quite a long time as a family solution for some afflictions. The main impediment that it endures is of low watery solvency and poor bioavailability. The point of the present examination was to build up a strategy for the readiness of nanoparticles of curcumin with a view to enhance its watery stage solvency and look at the impact on its antimicrobial properties.
  • Nanoparticles of curcumin (nanocurcumin) were set up by a procedure dependent on a wet-processing system and were found to have a restricted molecule estimate circulation in the scope of 2-40 nm. In contrast to curcumin, nanocurcumin was observed to be openly dispersible in water without any surfactants. The substance structure of nanocurcumin was the equivalent as that of curcumin, and there was no adjustment amid nanoparticle readiness. A base inhibitory centralization of nanocurcumin was resolved for an assortment of bacterial and parasitic strains and was contrasted with that of curcumin. It was discovered that the watery scattering of nanocurcumin was considerably more powerful than curcumin against Staphylococcus aureus , Bacillus subtilis , Escherichia coli , Pseudomonas aeruginosa , Penicillium notatum , and Aspergillus niger . The system of antibacterial activity of curcumin nanoparticles was examined by transmission electron micrograph (TEM) examination, which uncovered that these particles entered inside the bacterial cell by totally breaking the cell divider, prompting cell passing.

Keywords:- CURCUMIN,NAOPARTICLES,NANOCURCUMIN.


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References


Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. Curcumin and cancer: An “old-age” disease with an “age-old” solution. Cancer Lett 2008; 267:133-64.

Thadkala K, Nanam PK, Rambabu B, Sailu C, Aukunuru J. Preparation and characterization of amorphous ezetimibe nanosuspensions intended for enhancement of oral bioavailability.Int J Pharm Investig 2014;4:131-7

Viswanath G, Jithan A, Reddy VM. Development of new delivery strategies to increase bioavailability of curcumin. Int J Pharm Sci Nanotechnol 2009;1:335-40

Jithan A, Madhavi K, Madhavi M, Prabhakar K. Preparation and characterization of albumin nanoparticles encapsulating curcumin intended for the treatment of breast cancer. Int J Pharm Investig 2011;1:119-25.

Senthilkumar M, Mishra P, Jain NK. Long circulating PEGylated poly(D,L-lactide-co-glycolide) nanoparticulate delivery of Docetaxel to solid tumors. J Drug Target 2008;16:424-35.

Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as “Curecumin”: From kitchen to clinic. Biochem Pharmacol 2008;75:787-809

http://www.ijpsonline.com/articles/preparation-and-characterization-of-pegalbumincurcumin-nanoparticles-intended-to-treat-breast-cancer.pdf

https://www.ncbi.nlm.nih.gov/pubmed/21322563

https://pubs.acs.org/doi/10.1021/jf104402t


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